Opportunity Information: Apply for CDC RFA GH21 2125
The grant opportunity titled "Prevention and Control of Infections/Epidemics/Pandemics of Patients at Risk or Infected with HIV and/or TB/HIV in South Africa under PEPFAR" (Funding Opportunity Number CDC RFA GH21-2125) is a CDC cooperative agreement focused on strengthening infection prevention and control (IPC) in South Africa to reduce infections that people acquire through healthcare or institutional exposure (iatrogenic infections). The central public health problem it targets is that people living with HIV (PLHIV) face higher risks of acquiring infectious diseases and experiencing severe outcomes, particularly from tuberculosis (TB) and emerging epidemic or pandemic threats such as COVID-19. Because PLHIV often depend on frequent contact with health services, the quality and clarity of IPC practices in facilities and surrounding communities can directly affect morbidity and mortality.
A key motivation for the program is that existing IPC guidance has not consistently kept pace with modern epidemic and pandemic realities. The NOFO highlights common issues that undermine effective implementation: some guidelines do not address current outbreak scenarios, others offer conflicting recommendations across sources, and many fail to provide practical direction on high-stakes operational questions such as when and how to partially or fully close a facility, how to manage environmental cleaning and disinfection at the appropriate intensity, and how to handle staff quarantine and isolation without collapsing service delivery. Frequent updates to guidance, while often necessary during fast-moving outbreaks, can also create confusion and anxiety among healthcare workers, facility leadership, and community stakeholders if not communicated clearly and consistently. This funding opportunity is designed to close those gaps by improving both the technical quality of IPC standards and the systems that translate standards into day-to-day practice.
The program is structured to build IPC capacity across multiple layers of the health system, specifically at the national, provincial, and district levels, and also among District Support Partners (DSPs). A major deliverable is the development at the national level of scientifically sound policies, guidelines, and training curricula that can be adopted and used consistently across settings. The focus is not only on drafting documents, but also on ensuring that guidance is practical, aligned across stakeholders, and usable during routine operations as well as during outbreaks and emergencies. In addition to policy and training development, the opportunity calls for the creation of rapidly deployable "squad teams" that can be sent to facilities experiencing outbreaks or major IPC breakdowns, with the purpose of quickly identifying gaps, stabilizing the situation, and supporting corrective actions. This rapid response component is meant to prevent localized outbreaks in facilities (including health and correctional facilities) from escalating and to protect both patients and staff.
Another pillar of the work is stakeholder education and communication. Recipients are expected to educate key stakeholders on scientifically grounded IPC practices so that implementation is not limited to specialists but is understood by leadership, frontline staff, and partners who influence facility and community practices. The NOFO also emphasizes making relevant IPC information available through existing health information repositories, such as the Knowledge Hub, so that updated guidance, training materials, and practical tools can be accessed in a centralized and familiar location. This is intended to reduce fragmentation, improve consistency, and make it easier for facilities and partners to keep up with changes during epidemics and pandemics.
Meaningful involvement of affected communities is explicitly required. The opportunity states that key stakeholders, including representatives of PLHIV, should be meaningfully involved in planning, implementation, monitoring, and continuous improvement of IPC activities. In practical terms, this points to expectations around inclusive governance, feedback loops, and transparency, ensuring that IPC policies and outbreak responses reflect the realities faced by PLHIV and do not inadvertently create barriers to care, increase stigma, or ignore community-level risks.
Administratively, this is a discretionary funding opportunity under the health activity category (CFDA 93.067) administered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Center for Global Health. The funding instrument is a cooperative agreement, which typically implies substantial federal involvement and collaboration during implementation compared with a standard grant. Eligibility is listed as unrestricted, meaning a wide range of entity types can apply, subject to any additional eligibility clarifications within the full announcement. CDC anticipated making two awards. For funding, the notice states that the award ceiling for Year 1 is listed as 0 (none), while also indicating an anticipated approximate total of $10,000,000 in fiscal year funding for Year 1, contingent on the availability of funds. The opportunity was created on January 13, 2021, with an original closing date of March 14, 2021, and applications were due electronically by 11:59 p.m. Eastern Time on the deadline date.
In short, the opportunity is aimed at reducing preventable infections among PLHIV in South Africa by modernizing and harmonizing IPC guidance, building capacity across the health system and partner networks, establishing rapid response teams for outbreak-related IPC gaps, improving stakeholder training and communication, centralizing access to IPC resources, and ensuring that PLHIV voices and other key stakeholders are actively involved in shaping and improving IPC efforts across facilities and communities.Apply for CDC RFA GH21 2125
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Prevention and Control of Infections/Epidemics/Pandemics of Patients at Risk or Infected with HIV and/or TB/HIV in South Africa under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Jan 13, 2021.
- Applicants must submit their applications by Mar 14, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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