Opportunity Information: Apply for PA 27 036
The NIH Research Education Program - Research Experiences (Parent R25, Clinical Trial Not Allowed) is a discretionary NIH grant opportunity designed to fund structured research education activities that sit alongside, strengthen, or broaden the biomedical, behavioral, and clinical research training pipeline in the United States. Rather than supporting a specific hypothesis-driven research project, this R25 mechanism is meant to build and improve educational experiences that help develop a capable research workforce and expand exposure to research careers. The program is positioned as a workforce-focused investment: it supports educational activities that complement and/or enhance existing training, helps recruit people from particular specialty or disciplinary backgrounds into research careers, and improves understanding of research and its broader implications for health and society.
A core expectation is that the applicant organization provides clear institutional backing for the proposed program. NIH is explicit that the sponsoring institution must assure support, and that "institutional commitment" should be tangible, not just symbolic. In practice, that means applicants are expected to demonstrate they have the staff, facilities, and educational resources to run the program well, such as qualified program leadership and mentors, administrative support, training spaces or laboratories (as appropriate for the experience), and access to educational infrastructure needed to deliver the planned activities. The emphasis is on delivering high-quality, organized research education experiences that are feasible and well-supported within the host environment.
The opportunity is also designed to fit within ecosystems that already have training grants or other federally funded training programs. Organizations that hold Ruth L. Kirschstein NRSA institutional training grants (for example, T32 awards) or other federal training support are still allowed to apply, but the R25-supported experiences must be distinct from what is already being funded. NIH signals that, in many cases, it expects an R25 program to complement ongoing research training at the institution, filling gaps, offering specialized exposure, or creating structured experiences for participants who are not covered by other mechanisms. The key compliance point is avoiding duplication of federally supported training activities while still delivering meaningful, additive educational value.
This specific parent announcement is "Clinical Trial Not Allowed," meaning the proposed research education program cannot include clinical trials as part of what is being supported under the award. While participants may learn about clinical research concepts and may engage in research education broadly, the program itself cannot propose or support clinical trial activities under NIH definitions for this funding opportunity. Applicants typically need to ensure their planned experiences and descriptions align with NIH policy language on what constitutes a clinical trial, since NIH draws that boundary carefully.
Eligibility is broad across many U.S.-based organization types, reflecting NIH's intent to enable research education programs in a wide range of settings. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations (other than small businesses) as well as small businesses; and other eligible entities as listed in the notice. Because eligibility can depend on details and NIH has additional criteria in the formal announcement, applicants are directed to review Section III of the NOFO for full requirements and any special conditions.
At the same time, NIH draws a firm line on foreign involvement for this opportunity. Non-U.S. entities (foreign organizations) are not eligible to apply. Non-U.S. components of U.S. organizations are also not eligible to apply, and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In practical terms, the program must be organized and executed without foreign components under NIH policy, and applicants should design program activities, sites, and administration accordingly.
From an administrative standpoint, this opportunity is issued by the National Institutes of Health under Funding Opportunity Number PA-27-036. It is a grant funding instrument in the health activity category and is associated with multiple CFDA/assistance listing numbers, reflecting participation across NIH institutes and centers. The opportunity is open on a multi-year schedule, with an original closing date listed as 2029-05-05, which generally indicates recurring due dates or an extended availability window typical of NIH parent announcements. The excerpt provided does not specify an award ceiling or expected number of awards, so applicants usually need to consult the full NOFO and institute-specific guidance to understand likely budget ranges, project periods, and review considerations.
Overall, this R25 parent opportunity is best understood as support for well-planned research education "experiences" that help produce a stronger, better-prepared research workforce, widen entry points into research careers, and improve research literacy, while requiring strong institutional commitment, non-duplicative programming relative to other federally funded training, and full compliance with the prohibition on clinical trials and foreign components.Apply for PA 27 036
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Research Education Program - Research Experiences (Parent R25 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.233, 93.242, 93.273, 93.279, 93.310, 93.313, 93.361, 93.398, 93.837, 93.838, 93.839, 93.840, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879, 93.T21, 93.THR.
- This funding opportunity was created on 2026-06-08.
- Applicants must submit their applications by 2029-05-05.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH Research Education Program - Research Experiences (Parent R25, Clinical Trial Not Allowed) (PA-27-036)
What is this grant opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity under the Research Education Program - Research Experiences (Parent R25). It supports structured research education activities intended to strengthen, broaden, or complement the biomedical, behavioral, and clinical research training pipeline in the United States.
What is the main purpose of the R25 mechanism in this announcement?
The purpose is workforce-focused: to build and improve organized educational experiences that develop a capable research workforce, expand exposure to research careers, and improve understanding of research and its broader implications for health and society.
Does this funding support a specific hypothesis-driven research project?
No. This R25 mechanism is not intended to fund a specific hypothesis-driven research project. Instead, it funds research education experiences and structured educational activities that complement or enhance research training.
What kinds of activities are supported by this program?
The program supports structured research education activities that sit alongside, strengthen, or broaden existing research training. It is described as supporting educational experiences that complement and/or enhance existing training, recruit people from particular specialty or disciplinary backgrounds into research careers, and improve research literacy and understanding of research implications.
How does NIH describe the expected focus of the program?
NIH positions this as an investment in the research workforce. The emphasis is on delivering high-quality, organized research education experiences that are feasible, well-supported, and additive to what already exists in the training environment.
What does "institutional commitment" mean for this opportunity?
NIH expects clear, tangible institutional backing for the proposed program, not merely symbolic support. The institution is expected to assure support and demonstrate it can run the program effectively with appropriate staffing, facilities, and educational resources.
What examples of tangible institutional support are mentioned?
The opportunity highlights expectations such as qualified program leadership and mentors, administrative support, training spaces or laboratories (as appropriate), and access to educational infrastructure needed to deliver the planned activities.
Can organizations with existing federal training grants (such as T32) apply?
Yes. Organizations that hold Ruth L. Kirschstein NRSA institutional training grants (for example, T32 awards) or other federal training support are still allowed to apply.
If an institution already has training grants, how must the R25 program relate to them?
The R25-supported experiences must be distinct from what is already being funded. NIH expects the R25 to complement ongoing research training, fill gaps, offer specialized exposure, or create structured experiences for participants not covered by other mechanisms.
What is the key compliance issue related to existing federally funded training?
Avoiding duplication of federally supported training activities. The R25 program must deliver meaningful, additive educational value without duplicating activities supported by other federal training mechanisms.
What does "Clinical Trial Not Allowed" mean in this announcement?
It means the proposed research education program cannot include clinical trials as part of what is supported under the award. The program must be designed so that it does not propose or support clinical trial activities under NIH definitions for this funding opportunity.
Can participants still learn about clinical research or clinical research concepts?
Yes, participants may learn about clinical research concepts and engage in research education broadly, but the program itself cannot propose or support clinical trial activities under NIH definitions for this opportunity.
Why is it important to align program descriptions with NIH policy on clinical trials?
NIH draws the boundary carefully on what constitutes a clinical trial. Applicants typically need to ensure planned experiences and how they are described align with NIH policy language to remain compliant with the "Clinical Trial Not Allowed" restriction.
Who is eligible to apply?
Eligibility is broad across many U.S.-based organization types. The excerpt lists eligible applicants including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations (other than small businesses) as well as small businesses; and other eligible entities as listed in the notice.
Where should applicants confirm full eligibility rules and any special conditions?
Applicants are directed to review Section III of the NOFO for full requirements and any special conditions, since eligibility can depend on details and NIH may include additional criteria in the formal announcement.
Are foreign organizations eligible to apply?
No. Non-U.S. entities (foreign organizations) are not eligible to apply for this opportunity.
Are non-U.S. components of U.S. organizations eligible to apply?
No. Non-U.S. components of U.S. organizations are not eligible to apply.
Are foreign components allowed in the program?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed. The program must be organized and executed without foreign components under NIH policy.
What should applicants consider when designing program sites and activities?
Applicants should design program activities, sites, and administration to comply with NIH policy prohibiting foreign components for this opportunity and to ensure the program is executed without foreign components.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is PA-27-036.
Which agency issues this funding opportunity?
This opportunity is issued by the National Institutes of Health (NIH).
What type of funding instrument is this?
It is a grant funding instrument.
What is the activity category associated with this opportunity?
The activity category is health.
Is this opportunity tied to assistance listing (CFDA) numbers?
Yes. The opportunity is associated with multiple CFDA/assistance listing numbers, reflecting participation across NIH institutes and centers.
How long is this opportunity expected to be open?
The opportunity is described as open on a multi-year schedule, with an original closing date listed as 2029-05-05, which often indicates recurring due dates or extended availability typical of NIH parent announcements.
Does the provided excerpt state an award ceiling or expected number of awards?
No. The excerpt does not specify an award ceiling or the expected number of awards. Applicants typically need to consult the full NOFO and institute-specific guidance for likely budget ranges, project periods, and review considerations.
How should applicants think about this opportunity overall?
It is best understood as support for well-planned research education experiences that strengthen the research workforce, widen entry points into research careers, and improve research literacy, while requiring strong institutional commitment, non-duplicative programming relative to other federally funded training, and compliance with the prohibitions on clinical trials and foreign components.
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