Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed) | RFA RM 27 015

Opportunity Information: Apply for RFA RM 27 015

The NIH is soliciting applications for a single cooperative agreement (U24; clinical trials not allowed) to establish and run the Logistics Center for the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program (Funding Opportunity Number RFA-RM-27-015; CFDA 93.310). PRIMED-AI is a broader NIH initiative (with companion funding opportunities) aimed at accelerating the development of innovative, reliable, cost-effective, and sustainable AI-based clinical decision support (CDS) tools that combine clinical imaging with other kinds of health data. In practical terms, the program is focused on multimodal AI approaches that do not treat imaging as a standalone input, but instead fuse imaging with other patient-level data streams (for example, clinical variables and other relevant health data types) to support more personalized care across a range of diseases and clinical settings. A major emphasis is moving these tools toward real-world use by catalyzing adoption into clinical workflows, rather than leaving them as isolated research prototypes.

This specific NOFO is not primarily about building the AI models themselves; it is about creating the central coordinating hub that helps the entire PRIMED-AI consortium function effectively and have broader impact. The Logistics Center is expected to facilitate and coordinate program activities across funded teams, organize shared processes, and make sure that knowledge and outputs produced by the consortium are collected, organized, and communicated in ways that help the scientific, clinical, and patient communities actually find and use them. Because this is a cooperative agreement, NIH will have substantial involvement, and the awardee should be prepared to work in a highly collaborative, programmatic environment where coordination, responsiveness, and continuous alignment with NIH and consortium needs are part of the core job.

Structurally, the Logistics Center will be organized around three integrated Cores: an Administration Core, an Evaluation Core, and an Outreach Core. The Administration Core is the operational backbone, responsible for overall coordination of consortium activities, planning and running meetings, maintaining communication channels, tracking milestones, supporting governance processes, and generally keeping cross-site collaboration moving smoothly. The Evaluation Core is expected to assess progress and impact across PRIMED-AI activities, which typically includes developing evaluation frameworks, collecting consistent metrics, monitoring deliverables, and helping the consortium understand what is working, what is not, and where adjustments are needed to maximize real-world utility and sustainability. The Outreach Core focuses on dissemination and engagement, which includes building awareness of PRIMED-AI tools and resources, facilitating access to information about what the consortium is producing, and tailoring communications to different audiences such as researchers, clinicians, health system stakeholders, and patient communities. A key expectation across these Cores is that the Logistics Center will work closely with the other PRIMED-AI award recipients to collect, curate, and disseminate information about the tools developed within PRIMED-AI, with the explicit goal of enabling widespread awareness and access.

The funding mechanism is a U24 cooperative agreement under the NIH, categorized under Health. The opportunity has an estimated award ceiling of $575,000 (as listed in the source information), and NIH expects to make one award, meaning a single organization will serve as the program’s Logistics Center. The original application closing date is October 2, 2026, and the opportunity was created on June 30, 2026. Eligibility is broad across U.S.-based applicant types and includes state, county, and local governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized tribal governments and other tribal organizations; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses, among others listed in the NOFO. However, non-U.S. entities are explicitly not eligible: foreign organizations cannot apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.

Overall, the opportunity is best understood as a coordination and enablement award designed to make the PRIMED-AI ecosystem run well and reach beyond the consortium itself. The successful applicant will need to demonstrate strong program management and consortium coordination capabilities, a credible approach to evaluating progress and impact across diverse projects, and an outreach and dissemination strategy that helps PRIMED-AI outputs become visible, accessible, and usable by the broader communities that can benefit from multimodal imaging-plus-data AI decision support.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Logistics Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U24 Clinical Trials Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
• This funding opportunity was created on 2026-06-30.
• Applicants must submit their applications by 2026-10-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $575,000.00 in funding.
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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